Malakasa Any patient with a first seizure during this 1-year period was examined by physicians from the Department of Neurology and followed imlpenem quarterly until death or study end. Sign in to download free article PDFs Sign in to access your subscriptions Sign in to your personal account. Purchase access Subscribe now. While seizures tended to be well controlled with the use of phenytoin, the duration of follow-up is insufficient to estimate effectiveness. First seizure was generalized in 12 patients Carbamazepine therapy was discontinued in both patients because of adverse effects severe skin reaction and ataxia and was changed to phenytoin.
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Gulkree Previous studies have ranged from Van Paesschen et al 8 report a higher occurrence of status epilepticus in patients with IVDU than in other risk factor groups. Copyright American Medical Association. A cause was identified in most of our patients Any patient with a first seizure during this 1-year period was examined by physicians from the Department of Neurology and followed up quarterly until death or study end. Examination included testing glucose and serum electrolyte levels, liver and renal function, blood cell count, serologic tests for Toxoplasma gondii and cytomegalovirus, computed tomographic or magnetic resonance imaging brain scans, and, if required, toxicologic screens, electroencephalographic and cerebrospinal fluid studies biochemical tests, serologic tests for syphilis and T gondii, Gram stain, cultures for Cryptococcus neoformans and Mycobacteriumstains for acid-fast Bacillusand polymerase chain reaction for herpes simplex virus.
We studied patients both outpatients and inpatients for only 1 year; if the inclusion period had been longer, the occurrence might have been higher. Metabolic derangements hypoglycemia and hypomagnesemia were observed in 2 patients No complex partial seizures were observed. In the literature, seizures have been reported as a presenting manifestation of HIV-related disease in 3. In 1 patient, imipenem produced a GTC seizure, a well-known adverse effect. Drug toxicity was considered a definite covulsiones probable cause when the time was close between use of the drug and the seizure.
The reported higher percentages are possibly because of the inclusion of only inpatients in the advanced disease stages and a longer follow-up than in our study. Future extensive prospective studies with longer follow-up and pathological examination are needed to determine the significance of epileptic seizures in HIV-infected patients.
Hypomagnesemia can induce epileptic seizures, and Van Paesschen et al 8 emphasize metabolic causes as important in HIV-infected patients. Mean follow-up was 5. J Neurol Neurosurg Psychiatry. The risk of seizures among the carbapenems: a meta-analysis. Sign in to download free article PDFs Sign in to access your subscriptions Sign in to your personal account. Neurotoxicity due to use of zidovudine has been convulsiiones recognized as a convulaiones of epileptic seizures.
Seizures were refractory to therapy in 3 patients We found partial seizures in While seizures tended to be well controlled with the use of phenytoin, the duration of follow-up is insufficient to estimate effectiveness. Unlike previous studies according to our study, toxic-metabolic factors accounted for more than half The HIV stage was less advanced in those with no identifiable cause than in those with an identifiable cause.
A variety of other causes have been associated with HIV-infected patients who have seizures convklsiones, neoplasm, and stroke38 — — 26 but we did not see these causes in our patients. Lethal neurotoxicity associated to azidothymidine therapy. This disease was first described as a cause of seizures in Thus, in contrast to other authors, 14 we did not find a relationship between status epilepticus and poor outcome.
Neurological complications of acquired immunodeficiency syndrome: Get free access to newly published articles. We were able to identify the cause of seizure in Sign in to save your search Sign in to your personal account.
Create a personal account to register for email alerts with links to free full-text articles. In our series, seizure was never the presenting feature of HIV infection.
N Engl J Med. Prior to their first seizure, 14 patients Sign in to access your subscriptions Sign in to your personal account. Create a free personal account to access your subscriptions, sign up for alerts, and more. At the time of first seizure, 14 Only 1 patient with cerebral TXP had refractory seizures. Most patients were treated with phenytoin, which was well tolerated and effective in controlling seizures. In other reports, sexual transmission was the most common risk factor.
Seizures were well controlled with treatment. AIDS-associated progressive multifocal leukoencephalopathy revealed by new-onset seizures. Related Posts
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