Temoe lawak. In der Apotheker-Zeitung , 8, ff. Peyer und H. Dieser Irrtum wurde berichtigt durch C.

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Received Aug 4; Accepted Oct This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This article has been cited by other articles in PMC. Abstract The antioxidant activity of the curcuminoids of Curcuma domestica L. The methanol extracts and rhizome oils of C.

Curcumin, demethoxycurcumin, and bisdemethoxycurcumin, isolated from the methanol extracts of both plants, exhibited stronger activity than probucol IC50 value 0. Xanthorrhizol, the most abundant component The major components of C. The high levels of curcuminoids in the methanol extracts and xanthorrhizol, ar-turmerone and zerumbone in the oils, and in combination with the minor components were responsible for the high LDL antioxidant activity of the herbs.

Introduction Curcuma Zingiberaceae is a large genus of rhizomatous herbs distributed in tropical and subtropical regions especially in India, Thailand, the Malay Archipelago, Indochina, and Northern Australia.

Many species have been cultivated, and their powdered rhizomes have been widely used as flavours in native dishes and ingredients in many traditional medicines to treat various ailments [ 1 ]. The more popular and economically more important species, C. Many phytochemical studies on the extracts and essential oils of several Curcuma species, especially C.

The antioxidant activity of Curcuma species, especially C. Inhibitory activity of curcumin from C. The need to use different methods of antioxidant capacity measurement is due to the various mechanisms of antioxidant action.

Determination of the antioxidant activity of plant extracts and compounds often gave different results as the methods used are based on different reaction mechanisms [ 12 ]. Although the chemical constituents of Curcuma species have been reported and their antioxidant activity has been demonstrated, there has been little effort to correlate the chemical constituents and their antioxidant activity, and the actual substances contributing to the antioxidant activity have not been identified.

Direct evidence of therapeutic benefits of the plants and their compounds in cardiovascular disorders remains sparse, and data on LDL oxidation have been few. In a search for sources of natural cardiovascular protective agents for pharmaceutical, food, and nutraceutical applications, we investigated the antioxidant effect of the methanol extracts and essential oils of C.

The antioxidant activity was determined against copper-mediated isolated human LDL oxidation. Three major curcuminoids, that is, curcumin, demethoxycurcumin, and bisdemethoxycurcumin, were isolated from the methanol extract of the rhizomes of both herbs.

The structures of the major compounds are shown in Figure 1.


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